Cancer Biology Journal Club

2016-2017 Year:

Spring Quarter 2017 – Cancer Biology & Immunology Joint

Mondays – 12:00-12:50pm
Sprague Hall Conference Room 105
Instructor: Armando Villalta

Winter Quarter 2017

Mondays – 12:00-12:50pm
Sprague Hall Conference Room 105
Instructor: Robert Spitale & Klemens Hertel

Fall Quarter 2016

Mondays – 12:00-12:50pm
Sprague Hall Conference Room 105
Instructor: Marian Waterman & Kai Kessenbrock

Previous Cancer Biology Journal Club Schedules:

Winter Quarter 2016

Mondays – 12:00-12:50pm
Sprague Hall Conference Room 105
Instructor: Peter Kaiser

1/4 Dr. Kaiser Class orientation & Workshop on Bioinformatics Web Tools for Cancer Biologists
1/11 Amber Habowski & Stephanie Sprowl
1/18 Jordan Thompson & Luke Nelson
1/25 Sohail Jahid & Hsiang Ho RIP Talks
“PAK1 (P21-Activated Kinase 1) as a Therapeutic Target in Melanoma”
2/1 Liza Selwan & Alison McCracken
2/8 Dail Chapman & Stephanie Wu
2/15 Carolina Greco & Stefan Brooks
2/22 Stephanie Sprowl &
Jeffrey Briggs & Shae Victoria
RIP Talks
“Role of Wnt Signaling in Colon Cancer Cell Metabolism- Focus on Monocarboxylate transporter 1 (MCT1)”
“Towards Bladder Cancer Biosensors through Biomarker Production and Targeting”
2/19 Rebekah Dyer & Rachel Chow
3/7 Manuel Ramirez & Seong Min Kim
3/14 Archna Ravi & Da-Wei Lin RIP Talks
“’Macropinocytosis confers low nutrient survivability in cancer cells”
“Methionine Stress sensitivity in human cancer cells”

Spring Quarter 2013

Mondays – 12:00-1:30pm
Sprague Hall Conference Room 105
Instructor: Christine Suetterlin

Date Presenter Topic/Paper Title
4/1/13 Dr. Suetterlin
4/8 Mary Ziegler Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function
4/15 Thanh-Trang Vo Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and Autophagy
4/22 Stephanie Sprowl Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties
4/29 Judy Webb Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA
5/6 Scott Hollingworth
5/13 Michelle Chen
5/20 Alison McCraken
5/27 Memorial Day (No Class)
5/3 Andria Denmon

Winter Quarter 2013

Mondays – 12:00-1:30pm (class on Feb 4th & Mar 4th start at 12:30)
Sprague Hall Conference Room 105
Instructor: David Fruman

Date Presenter Topic/Paper Title
1/9/13 Dr. Fruman Intro session and discussion
1/16 Trang Vo Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR
1/23 Alison McCracken Synthetic Lethal Interaction of Combined BCL-XL and MEK Inhibition Promotes Tumor Regressions in KRAS Mutant Cancer Models
1/28 Bradley Wallentine PI3K Inhibition Impairs BRCA1/2 Expression and Sensitizes BRCA-Proficient Triple-Negative Breast Cancer to PARP Inhibition
2/4 Jack Chen Enhancing Tumor-Specific Uptake of the Anticancer Drug Cisplatin with a Copper Chelator
2/11 Dipa Batabyal Trastuzumab-Resistant Cells Rely on a HER2-PI3K-FoxOSurvivin Axis and Are Sensitive to PI3K Inhibitors
2/18 Michelle Chen Activation of p53 by SIRT1 Inhibition Enhances Elimination of
CML Leukemia Stem Cells in Combination with Imatinib
2/25 Jennifer Lee Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B
3/4 Judy Webb SpliceArray Profiling of Breast Cancer Reveals a Novel Variant of NCOR2/SMRT That is Associated with tamoxifen Resistance and Control of Era Transciptional Activity
3/11  Amy Hopkin Relief of Profound Feedback Inhibition of Mitogenic Signaling by RAF Inhibitors Attenuates Their Activity in BRAFV600E Melanomas

Fall 2012
Tuesdays, 12-1:30pm
Sprague Hall Conference Room B002
Facilitator: Dr. Ganesan

Theme for fall quarter: Systems Biology of Cancer
Students should be aware of review criteria used by high profile journals to judge whether papers are suitable for publication. I have copied the reviewer guidelines for the nature journals. For the journal club, I want the students to primarily select papers from journals with impact factor 7 or higher. This makes for a more robust discussion.
See these reviewer guidelines from the nature journals.

Date Presenter Topic / Paper Title (link to paper)
10/2 Ganesan Class orientation-Systems Biology of Cancer
10/9  Kristine Germar(Guest speaker)  T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling
10/16  No Class
10/23 Min Kim Seong
Michelle Chen
 A unifying model for mTORC1-mediated regulation of mRNA translation
The translational landscape of mTOR signaling steer cancer initiation and metastasis
10/30 Jennifer Lee
Tom O’Sullivan
Acquired resistance to small molecule ErbB2 Tyrosine Kinases inhibitor
The glucose -deprivation network counteracts lapatinib-included toxicity in resistant ErbB2-positive breast cancer cells
11/6 Tiffany Kwong
Amy Hopkin
 Mapping the hallmarks of Lung Adenocarcinoma with massively parallel sequencing
Genomic landscape of Non-Small Cell Lung Cancer in smoker and Never-Smoker
11/13 Trang Vo Bc1-2 Family Genetic Profiling Reveals Microenvironment-Specific determinants of chemotherapeutic response
11/20  No Class
11/27 Jack Chen
Dipa Batabyal
Global investigation of p53-induced Apoptosisthrough quantitative proteomic profiling using comparative amino acid-coded tagging
Tumor suppression in the absence of p52-mediated cell-cycle arrest, apoptosis, and senescence
12/4 Alison McCracken
Manuel Ramirez
“Glycine Decarboxylase Activity drives non-small cell Lung Cancer Tumor-initiating cells an dTumorigenesis”
“Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation”


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