Phang-Lang Chen

Biological Chemistry, School of Medicine

Phone: (949) 824-4008

Email: plchen@uci.edu

 

Dr. Chen’s laboratory is interested in understanding the critical role of tumor suppressor genes in the genesis and progression of cancer. Currently, they are putting most of their efforts into elucidating the intracellular signaling pathways involved in the DNA damage response. They are focusing on molecules serving as transducers and effectors, including BRCA1 and BRCA2, members of the BRCT motif-containing family proteins such as NBS1, 53BP1 and NFBD1, and on the DNA repair machinery.  Understanding these signal pathways is vital for solving the puzzle of how cells maintain their genome stability and how specific problems with DNA repair predispose to different cell type-specific cancers.

Recent Publications:

Chen Y, Chen CF, Polci R, Wei R, Riley DJ, Chen PL. Increased Nek1 expression in renal cell carcinoma cells is associated with decreased sensitivity to DNA-damaging treatment. Oncotarget. 2014 Jun 30;5(12):4283-94. PMID:24970796

Wang DD, Guo XE, Modrek AS, Chen CF, Chen PL, Lee WH.  Helicase SUV3, polynucleotide phosphorylase, and mitochondrial polyadenylation polymerase form a transient complex to modulate mitochondrial mRNA polyadenylated tail lengths in response to energetic changes. J Biol Chem. 2014 Jun 13;289(24):16727-35. doi: 10.1074/jbc.M113.536540. Epub 2014 Apr 25. PMID:24770417

Zhu J, Zhou L, Wu G, Konig H, Lin X, Li G, Qiu XL, Chen CF, Hu CM, Goldblatt E, Bhatia R, Chamberlin AR, Chen PL, Lee WH. A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia. EMBO Mol Med. 2013 Mar;5(3):353-65. doi: 10.1002/emmm.201201760. Epub 2013 Jan 22. PMID:23341130

Bothmer A, Rommel PC, Gazumyan A, Polato F, Reczek CR, Muellenbeck MF, Schaetzlein S, Edelmann W, Chen PL, Brosh RM Jr, Casellas R, Ludwig T, Baer R, Nussenzweig A, Nussenzweig MC, Robbiani DF. Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching. J Exp Med. 2013 Jan 14;210(1):115-23. doi: 10.1084/jem.20121975. Epub 2012 Dec 17. PMID:23254285

Wei PC, Hsieh YH, Su MI, Jiang X, Hsu PH, Lo WT, Weng JY, Jeng YM, Wang JM, Chen PL, Chang YC, Lee KF, Tsai MD, Shew JY, Lee WH. Loss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic disease. Mol Cell. 2012 Dec 14;48(5):747-59. doi: 10.1016/j.molcel.2012.10.007. Epub 2012 Nov 1. PMID:23123197

Guo XE, Chen CF, Wang DD, Modrek AS, Phan VH, Lee WH, Chen PL. Uncoupling the roles of the SUV3 helicase in maintenance of mitochondrial genome stability and RNA degradation. J Biol Chem. 2011 Nov 4;286(44):38783-94. doi: 10.1074/jbc.M111.257956. Epub 2011 Sep 12. PMID:21911497

Chen Y, Chen CF, Riley DJ, Chen PL. Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR. Cell Cycle. 2011 Feb 15;10(4):655-63. Epub 2011 Feb 15. PMID:21301226

Chen Y, Chen CF, Chiang HC, Pena M, Polci R, Wei RL, Edwards RA, Hansel DE, Chen PL, Mutation of NIMA-related kinase 1 (NEK1) leads to chromosome instability. Riley DJ. Mol Cancer. 2011 Jan 10;10(1):5. doi: 10.1186/1476-4598-10-5. PMID:21214959

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